Patient Identification
Is ZYNTEGLO indicated for your patient?
ZYNTEGLO is a one-time gene therapy that expands options for patients with transfusion-dependent β-thalassaemia (TDT)
≥12 years of age who do not have a β0/β0 genotype and who do not have an HLA-matched related donor.1
≥12 years of age who do not have a β0/β0 genotype and who do not have an HLA-matched related donor.1
CONSIDER TREATMENT FOR PATIENTS WHO MEET THESE CRITERIA1:
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Diagnosed with TDT
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Who do not have a β0/β0 genotype
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Patients ≥12 years of age
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Appropriate for haematopoietic stem cell transplant (HSCT)
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No human leukocyte antigen (HLA)–matched related haematopoietic stem cell donor available
CONTRAINDICATIONS1
- Hypersensitivity to the active substance or to any of the excipients
- Pregnancy and breastfeeding
- Previous treatment with HSC gene therapy
- Contraindications to the mobilisation agents and the myeloablative conditioning agent must be considered
Please consult the full Summary of Product Characteristics (SmPC) and the Prescribing Information (PI) before prescribing.
*Patients were considered to be transfusion-dependent if they had a history of transfusions of at least 100 mL/kg/year of RBCs or received ≥ 8 transfusions of RBCs per year in the 2 years preceding enrolment